Stable oral availability of sustained release propranolol when co-administered with hydralazine or food: Evidence implicating substrate delivery rate as a determinant of presystemic drug interactions

摘要

1 A study was made of the influence of hydralazine on the oral availability of a sustained release formulation of propranolol (Inderal LA®). Sustained release propranolol 160 mg was given orally either alone or in combination with oral hydralazine 25 mg on separate occasions to six healthy volunteers. Blood and urine samples were collected post-dosing over 34 h.